Senior Principal Scientist, Quantitative Biosciences Job at Merck, Boston, MA

  • Merck
  • Boston, MA

Job Description

Merck seeks a Senior Principal Scientist to lead mass spectrometry capabilities within the Quantitative Biosciences group in Boston. The role combines technical expertise in MS-based assay development with strategic leadership, mentorship, and collaboration across discovery programs to advance drug discovery decision-making.

Responsibilities

  • Lead Boston mass spectrometry group supporting in vitro and in vivo pharmacology discovery needs
  • Shape strategy for MS-enabled assay development, experimental design, and quantitative pharmacology applications
  • Partner with multidisciplinary teams to develop assays informing mechanism, potency, selectivity, and translational decisions
  • Provide scientific guidance to bench scientists on assay selection, study design, and data interpretation
  • Mentor and develop scientists while fostering culture of scientific rigor and collaboration across local and global teams

Requirements

  • Ph.D. in biology, pharmacology, analytical chemistry, biochemistry, pharmaceutical sciences, or related STEM field plus 12+ years pharmaceutical/biotech research experience
  • Deep expertise in mass spectrometry-based assay development and drug discovery applications
  • Strong understanding of drug discovery process from hit finding through lead optimization
  • Demonstrated experience applying quantitative pharmacology principles to biological systems
  • Proven scientific leadership record in biopharmaceutical setting with measurable impact on programs
  • Experience leading, mentoring, and developing scientists in research environments
  • Ability to design experiments independently, interpret complex data, and communicate findings to multidisciplinary teams

Compensation: $214,100–$337,000 base

Job Tags

Local area

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